small-molecular compounds Search Results


er stress inhibitor tudca  (TargetMol)
94
TargetMol er stress inhibitor tudca
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
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epigenetic modification  (TargetMol)
93
TargetMol epigenetic modification
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
Epigenetic Modification, supplied by TargetMol, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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small molecular compounds  (ChemNavigator com Inc)
90
ChemNavigator com Inc small molecular compounds
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
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molecular libraries small-molecule repository (mlsmr) library test compound  (Kalypsys Inc)
90
Kalypsys Inc molecular libraries small-molecule repository (mlsmr) library test compound
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
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20,000 small molecular weight compound library  (Chembridge)
90
Chembridge 20,000 small molecular weight compound library
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
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392 compounds of a molecular library of 5,000 nonpeptide small molecules  (NeuroSearch A/S)
90
NeuroSearch A/S 392 compounds of a molecular library of 5,000 nonpeptide small molecules
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
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small molecular weight compounds  (Evotec Inc)
90
Evotec Inc small molecular weight compounds
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
Small Molecular Weight Compounds, supplied by Evotec Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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small molecular compounds  (Chemdiv Inc)
90
Chemdiv Inc small molecular compounds
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
Small Molecular Compounds, supplied by Chemdiv Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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small molecular weight compound  (Takeda)
90
Takeda small molecular weight compound
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
Small Molecular Weight Compound, supplied by Takeda, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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potent, small molecular weight, non-peptide, compounds  (TransTech Pharma)
90
TransTech Pharma potent, small molecular weight, non-peptide, compounds
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
Potent, Small Molecular Weight, Non Peptide, Compounds, supplied by TransTech Pharma, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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small molecule compound 7460-0250  (Molecular Dynamics Inc)
90
Molecular Dynamics Inc small molecule compound 7460-0250
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
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small molecular compound database  (Chemdiv Inc)
90
Chemdiv Inc small molecular compound database
Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M <t>TUDCA</t> for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).
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Image Search Results


Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).

Journal: Stem Cells International

Article Title: Mesenchymal Stem Cells Inhibit Epithelial-to-Mesenchymal Transition by Modulating the IRE1 α Branch of the Endoplasmic Reticulum Stress Response

doi: 10.1155/2023/4483776

Figure Lengend Snippet: Suppression of ER stress contributed to MSC-mediated amelioration of EMT in A549 cells. (a) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (b) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of BiP, ATF6, ATF4, XBP-1s and XBP-1u were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). (c) A549 cells were treated with 100 μ M TUDCA for different times. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 3, one-way ANOVA with Duncan's post hoc test). (d) A549 cells were treated with 10 ng/ml TGF- β 1 in the presence or absence of TUDCA for 72 hr. The protein expression levels of E-cadherin and vimentin were measured using western blotting and quantified using densitometry in ImageJ software ( n = 4, one-way ANOVA with Duncan's post hoc test). The data are shown as the means ± SEMs ( ∗∗ P < 0.01, ∗ P < 0.05 vs. the control group; ## P < 0.05, # P < 0.05 vs. the TGF- β 1 group).

Article Snippet: A549 cells were treated with TGF- β 1 (10 ng/ml, 100-21, PeproTech, Rocky Hill, NJ, USA) for 72 hr with or without pretreatment with the ER stress inhibitor TUDCA (100 μ M, abs816166; Absin, Shanghai, China) or IRE1 α -specific inhibitor 4 μ 8c (10 μ M, T6363, Topscience, Shanghai, China) for 1 hr.

Techniques: Expressing, Western Blot, Software, Control